Endothelial dysfunction & Cell miscommunication

Alumni members:
   Dr. Nihel Berrebeh, PharmD, PhD

                                  PhD (2019-2022), Postdoc (2023)

Nihel Berrebeh is a Doctor of Pharmacy and graduated from the University of Paris-Saclay with a PhD in Sciences under the supervision of Dr Ly TU and Dr Christophe Guignabert. After her PhD, she was doing a post-doctoral fellowship in the team to further investigate the role of the BMP9/ALK1/BMPR-II axis in the pulmonary endothelial dysfunction associated with pulmonary hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). More specifically, she was studying the effect of the modulation of this axis on the angiogenic potential of pulmonary microvascular endothelial cells as well as on the pulmonary vascular integrity and remodeling.
   Mustapha Chelgham

                                  Bioengineer (2020-2023)

Mustapha Chelgham has joined Dr Guignabert's Team in july 2020 as an Engineer. He gratuated from Angers University with a Master degree in Health Biology, specialized in Pathophysiology and Vascular Pharmacology. Mustapha was involved in all the projects led in the group to better understand the role of endothelial dysfonction in the pulmonary arterial hypertension. He performed different biological and biochimical analyzes and participated to the in vitro functional studies.

   Aye Myat Nyein

                                  Master Student

Aye Myat NYEIN holds a bachelor degree in pharmacy in Myanmar. She was doing an internship in the GUIGNABERT's team as part of her Master 2 « Development of Drugs and Health Products » at the Université Paris-Saclay, under the supervision of Dr Fabien ROBERT and Dr Ly TU. She joined an ongoing research program that is seeking to identify new molecular pathways underlying the development of hepatopulmonary syndrome (HPS), a pulmonary vascular complication of portal hypertension, with or without cirrhosis. To this aim, Aye studied comprehensive transcriptomic analyses of lungs with HSP induced by bile duct ligation and partial portal vein ligation.

  Dr. Athénaïs Boucly, MD, PhD


Athénaïs Boucly, pulmonologist with a PhD, joined the team in 2021 as a postdoc. She focused on the identification of novel biomarkers associated of the pronosis of PAH. She was also contributing to the project "RHU Destination 2024".

  Dr. Marie-Caroline Certain, MD

                                  Pneumologist, Master 2 (2021)

Marie-Caroline Certain, pneumologist, joined Dr Guignabert’s team in 2021 for a Master 2 internship in Cell biology, Physiology, Pharmacology of breathing and sleep. She received an one year fellowship ('Année de Recherche') to study the role of BMP9 in the physiopathology of hepatopulmonary syndrome under the co-direction of Dr Laurent Savale and Dr Christophe Guignabert.

     Dr. Etienne-Marie Jutant, MD, PhD

                                    PhD student(2019-2021)

Etienne-Marie Jutant, pulmonologist with a Master degree in Pharmacology from the University of Paris-Saclay, joined the team for his PhD with an INSERM grant (“Poste d’accueil INSERM”). Under the supervision of Dr Alice Huertas, he studied the role of inflammation in the pathogenesis of PAH, focusing on the role of type 1 cytokinic receptors and their regulation.
     Benjamin Le Vely
                                    Bioengineer (2018-2021)

Benjamin joined Dr Guignabert's team from September 2018 to August 2021 as an Engineer. Benjamin contributed to several projects of the team and, more spefcifically, he studied the role of cAbl in the maintenance of genome integrity in pulmonary endothelial cells. 

AlilceHuertas    Dr. Alice Huertas, MD, PhD
                                    Assistant Professor (CR1 INSERM) (2010-2021)

Alice joined Prof. Marc Humbert’s lab and obtained her PhD focusing on immune dysregulation and the onset of autoimmunity in pulmonary arterial hypertension (PAH). In particular, she highlighted that PAH patients display impaired regulatory T lymphocytes in a leptin-dependent manner. Alice investigated the crosstalk between endothelial dysfunction and pulmonary vascular remodeling in PAH, with a particular interest in the role of leptin signalling system in the pulmonary vascular wall.

Aboudrahamane Bate

                                   Master 2 student (2021)

Aboudrahamane joined Dr. Guignabert' Lab in February 2021 for a MSc. program. Under the supervision of Dr Ly Tu and Raphaël Thuillet, Aboudrahamane studied the vascular endothelium in chronic thromboembolic pulmonary hypertension (CTEPH) in order to determine the precise alterations that occur in the pulmonary endothelium during the disease progression.

    Dr. Mohamed Reda Amar Djessas, MD

                             Master 2 student (2020)

Mohamed Reda Amar Djessas received his MD in 2018 and he joined Dr. GuignabertLab in 2019 for a M.SC. program.Under the supervision of Dr Marie-Camille Chaumais and Dr Christophe Guignabert, he was studying the role of BMP9 in the susceptibility of rats deficient in Bmp9 to the development of experimental pulmonary hypertension.

     Dr. Jennifer Bordenave

                                    PhD student - (2015-19)

Jennifer Bordenave, graduated with a master of "Physiologie, Métabolisme et Physiopathologies humaines" from the University of Pierre et Marie Curie, did her PhD with Dr Christophe Guignabert (PhD fellowship from the Fondation pour la Recherche Médicale - "thèse en pneumologie"). Jennifer's research seeked to study the mechanisms underlying the increased pericyte coverage of remodeled distal pulmonary arteries in human and experimental PAH. In particular, she examined the transcriptome and cellular phenotype of pulmonary pericytes derived from control and PAH patients.
CarolePhan    Dr. Carole Phan

                                    PhD student - (2014-18) -

Current position: Research Engineer, Pasteur Institute, Paris, France.

Carole Phan, graduated with a master of 'Signalisation et systèmes intégrés en Biologie' from the University of EPHE-Sorbonne, realized her PhD with Dr Christophe Guignabert (PhD fellowship from the Fonds de Dotation "Recherche en Santé Respiratoire" - Fondation du Souffle). Carole's research seeked to study the cellular and molecular mechanisms induced by drug-induced Pulmonary Hypertension. In particular, she was investigating the importance played by the endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in the vulnerability of pulmonary endothelial cells (P-ECs) to environmental stimuli.
Paul-Benoît Poble

Master 2 student (November 2016 to November 2017)

Paul-Benoît POBLE is a resident in pulmonology. He completed a Master 1 in Cell and Molecular Biology at the University of Saint-Etienne. He was conducting a Master 2 (Biology, Physiology, Pharmacology of breathing and Sleep) and he was performing his internship under the direction of Dr.Christophe Guignabert. He obtained a scholarship from the Fonds de Dotation "Rechercheen Santé Respiratoire" (FRSR) and from the Fondation du Souffle (FdS) to conduct his research on the role of BMPRII and its signaling pathway in the pulmonary vein remodeling associated with PAH.

Dr Ayumi Sekine, MD, PhD
Post-Doc (October 2016 to October 2018)
Dr. Ayumi Sekine joined Dr. Christophe Guignabert’s group in September 2016. She gratuated from Tokyo Women’s Medical University School of Medicine in Japan in 2006. After completing her residency in Pulmonology in 2009 at Tokyo Saiseikai Central hospital, she worked in the Department of Pulmonology at Chiba University from 2010 to 2016. Ayumi Sekine obtained her PhD from Chiba University focusing on the morphology and mechanisms of tissue-resident progenitor cells in pulmonary circulation, under the supervision of Pr. Koichiro Tatsumi (Department of Pulmonology) and Pr. Nobuhiro Tanabe (Director of the faculty of Advanced Therapeutics for PH). In 2015, Dr. Sekine was appointed as Assistant Professor in the Faculty of Advanced Therapeutics for PH. In 2017, Ayumi was awarded by a Research Fellowship Grant from Uehara Memorial Foundation.

    Dr Satoshi Akagi, MD, PhD

                                      Post-Doc (December 2016 to May 2017)

Current position: Assistant Professor, Medical School, Okayama University, Japan.

Dr. Satoshi Akagi joined Dr. Christophe Guignabert’s group as a post-doctoral researcher in 2017. In 2000, he gratuated from the school of medecine of Yamaguchi University in Japan. After completing his residency in Cardiology at Okayama Medical Center, he worked in the Department of Cardiovascular Medicine at Okayama University Hospital from 2006 to 2016. In 2013, he obtained his PhD from Okayama University focusing on combination therapy in pulmonary hypertension under the supervision of Prof. Tohru Ohe (Okayama University) and Hiromi Matsubara (Department director of Okayama Medical Center).He has been appointed as Assistant Professor in Okayama University in 2013 and awarded a scholarship from Banyu Life Science Foundation International in 2015. His work focused on the regulation of uric acid metabolism in experimental and human PAH.

Noé Bagur

Pharmacy student (2017)

He joined our group fora 2-month research training. Under the supervision of Marie-Camille Chaumais and Christophe Guignabert, Noé was contributing to a research project focused on tyrosine kinase inhibitors and their effects on pulmonary endothelial cells.

 MariaRosaGhigna     Maria-Rosa Ghigna, MD, PhD
                              PhD student (2013-16) 
Current position: Pathologist at Marie Lannelongue Hospital
Maria-Rosa Ghigna is a pathologist in the 'centre chirurgical Lannelongue Marie' and obtained her PhD with Dr Christophe Guignabert and Dr. Peter Dorfmüller. Her work sought to assess how mutations in the bone morphogenetic protein receptor type 2 (BMPR2) affect the structure and function of the pulmonary arterial bed and EC biology in PAH. Therefor, Maria Rosa Ghigna has performed comparative histological analysis in order to explore and compare the histology and morphology of pulmonary vascular lesions in BMPR2 mutation carriers and noncarriers at the time of lung transplantation. Based on these histological observations, Maria-Rosa has also explored the relationships between VEGF and BMP signaling pathway and its role for the pulmonary vascular remodeling in PAH.

                              PhD - Post-Doc (2012-16)
Current position: Post Doctorant Cadre chez Sanofi, Chilly Mazarin, France.
Morane Le Hiress obtained her Ph.D in 2015 focusing on the "Role of the macrophage migration inhibitory factor (MIF) and its endothelial receptor CD74 in the proinflammatory signature of the dysfunctional pulmonary endothelium in Pulmonary Arterial Hypertension (PAH)" under the supervision of Dr. Christophe Guignabert. In addition, Morane has studied the role of the intracellular functions of MIF in the hyperproliferative and apoptosis resistant P-EC phenotype in idiopathic PAH.

YuichiTamura Dr Yuichi Tamura, MD, PhD
                               Post-Doc (2014-16) 
Current position: Director of Pulmonary Hypertension Center Associate Professor at the International University of Health and Welfare Mita Hospital, Tokyo, Japan.
Dr. Tamura graduated from Medical School at Keio University School of Medicine, Japan in 2004 and completed his residency in 2006. Dr. Tamura research interests were on cardiac regeneration and pulmonary hypertension (PH) under the supervision of Prof. Keiichi Fukuda (Keio University, Tokyo) and Prof. Toru Satoh (Kyorin University, Tokyo). He has been appointed Assistant Professor and Director of Faculty of Advanced Therapeutics for PH, Department of Cardiology, in Keio University School of Medicine in 2010. Since then, he is also leading the japanese PH registry system.
From June 2014 to March 2016, Dr. Yuichi Tamura received a personal Marie Curie grant for a post-doctoral fellowship and joined Prof. Marc Humbert's lab, as a post-doc. Under Dr. Christophe Guignabert's supervision, Yuichi focused on immune system disorders in patients with PAH, with a particular interest in interleukin (IL)-6 cis- and trans-signaling. Dr. Tamura has also participated to the clinical research at the National Reference Centre for PH, Department of Respiratory and Intensive Care Medicine, Bicêtre Hospital.
  Michiel De Raaf
                            Post-Doc (2015)
Michiel Alexander De Raaf, B.A.Sc. M.Sc., is an expert in data analysis in telemetry studies for Safety Pharmacology. In 2011, he started his PhD program at the VU University medical center (Amsterdam, The Netherlands). During his PhD Michiel focused on the characterization and potential drug evaluation in experimental Pulmonary Hypertension. In 2015, he joined Dr. Christophe Guignabert’s group funded by a personal long term fellowship grant from the European Respiratory Society. His work focused on the role of VEGF signaling pahtway in PAH.

EtienneMarieJutan  Etienne-Marie JUTANT, MD
                            Master student (2014-15)

NicolasRicard    Dr Nicolas Ricard, PhD
                               Post-doc (2012-14) 
Current position: Assitant professor (INSERM UMR1292)
Nicolas Ricard obtained a Master degree in Biochemistry and Biotechnology from the INSA Lyon in 2007. Then, he completed in 2011 his PhD in the laboratory of Dr. J.J.-Feige (INSERM UMR_S 1036) in Grenoble, under the direction of Dr. S. Bailly, on BMP9 and ALK1 in vascular remodeling. Next, he joined in 2012 our group to study the effects of pulmonary endothelial dysfunction on pericytes and the increased pericyte coverage of remodeled distal pulmonary arteries in human and experimental PAH.

Dr Caroline Sattler, MD
Master student (2012-13)
In 2012, Caroline Sattler joined our group for her MSc in 'Pharmacologie, Pharmacocinétique des produits de santé'. Caroline has examined the effects of interferon on pulmonary endothelial dysfunction and the structural and functional remodeling of the pulmonary vascular bed.

AndreiSeferian    Dr Andrei Seferian, MD
                             Master student (2011-12)
Current position: Praticien Hospitalier, Hôpital Bicêtre, Le Kremlin-Bicêtre, France. 
In 2011, Andrei Seferian joined our group for his MSc in 'Pharmacologie, Pharmacocinétique des produits de santé'. Andrei has studied the effects of dasatinib and imatinib on pulmonary endothelial dysfunction and pulmonary vascular remodeling.

FrancesdeMan    Frances Handoko - de Man, PhD
                               Post-doc (2010-11
Current position: Assistant professor at VU University Medical Center, Department of Pulmonary Medicine, Amsterdam, The Netherlands.
In 2010, Frances de Man received a personal Marie Curie grant for 1 year post-doctoral fellowship and joined Pr Marc Humbert's lab. Under supervision of Dr Christophe Guignabert and Pr Marc Humbert, she had investigated on the renin angiotensin aldosterone system (RAAS) system pathway in PAH and particularly on the cross-talk between 'smooth muscle cell' and 'endothelial cell'.

Tasnim Rahmani - Licence professionnelle Bio-industries et Biotechnologies (2023)

Maxime Surbier - Master Student

Mathieu Laidin - Undergraduate student BTS (2020)

Amélie Cumont - Engineer Assistant (2017-19)

Audrey Baron - Master student (2019)

Vinvent Ouaza De Paul - Undergraduate student BTS (2019)

Maryama Cisse - Undergraduate student BTS (2019)

Safaa Nemlaghi - Master student (2018)

Timothée Quatremare - Bioengineer (2017-18)

Kévin BertrandMaster student (2017-18)

Yannaëlle Rousseau - Engineering student (2016-17)

Lorna Leleu -  Undergraduate student BTS (2015-17)

Kevin Ganier - Engineering student (2014-15)

Fatima Aboualla -  Undergraduate student BTS (2014-15)

Clément Ripoll - Master student (2014-15)

Cindy Lobe - Master student (2013-2014)

Marie-Dielle Bilongo Undergraduate student (2013-2014)

Inès Aniambossou - Master student (2012-2013)

Krystel Brossar - Master student (2010-2011)

Yannick MBaki - Master student (2010-2011)

Charlène Joseph - Undergraduate student (2009-2010)